
基本信息:
吴振华,男,汉族,群众,江西赣州,硕士研究生导师,讲师,2023年获厦门大学理学博士学位,主要研究方向为肿瘤和心脑血管疾病的药物化学生物学研究。讲授有机化学、药物化学等课程。主持江西省科技厅面上项目1项、赣南医科大学高层次人才科研启动基金1项;参与国自然面上项目1项、重点项目1项。以第一作者在J. Med. Chem.、Eur. J. Med. Chem.、Bioorg. Chem.、Br. J. Pharmacol.、Anal. Methods等国际期刊发表SCI论文6篇。
科研成果列表:
(1) Wu, Z.; Liu, X.; Yan, X.-E.; Wu, X.; Huang, W.; Li, J.; Xiu, Y.; Lv, C.; Sun, C.; Wang, Z.; Xu, G.; Wu, X.; Hu, Z.; Huang, H.; Huang, X.; Zhang, J.; Yun, C.-H.; Li, L.; Deng, X. Discovery of Potent and Selective Pyrrolo[2,3-d]pyrimidine Derivatives as Fourth-Generation EGFR Inhibitors Targeting Triple Mutations. J. Med. Chem. 2025, 68 (18), 19205–19228.(共同第一作者,中科院1区)
(2) Wu, Z.; Zhu, X.; Hong, A.; He, G.; Wang, Z.; Xu, Q.; Hu, Z.; Wu, X.; Wang, Y.; Chen, Q.; Zhao, X.; Li, L.; Deng, X. Discovery of urea-based pleuromutilin derivatives as potent gram-positive antibacterial agents. Bioorg. Chem. 2023, 136, 106547.(共同第一作者,中科院1区)
(3) Wu, Z.; Fu, N.; Han, X.; Yan, T.; Zheng, J.; Yi, J. The visual detection of amoxicillin using a dual-mode probe based on CQD-doped MnO₂ nanospheres. Anal. Methods 2025, 17, 8171–8179.(第一作者,中科院3区)
(4) Wu, Z.; Liao, W.; Chen, K.; Qin, J.; Tang, H. Synthesis of Derivatives of Cleistopholine and Their Anti-Acetylcholinesterase and Anti-β-Amyloid Aggregation Activity. Bioorg. Chem. 2018, 76, 228–236.(第一作者,中科院1区)
(5) Gao, F.; Wu, Z.; Lin, A.; Wu, X.; Zhang, B.; Liu, L.; Lu, Y.; Geng, S.; Huang, Z.; Chen, Y.; Zhang, J.; Li, L.; Deng, X. Discovery of an ALK degrader for lorlatinib-resistant compound mutations. Eur. J. Med. Chem. 2025, 296, 117835. (共同第一作者,中科院1区)
(6) Xiao, C.; Wu, Z.; Liao, L.; Shi, C.; Gao, H.; Zhang, T.; Chen, Q.; Hou, Y.; Yun, C.-H.; Su, D.; Zhou, D.; Deng, X.; Chen, L. Pharmacological targeting of large tumor suppressor kinases (LATS) 1 and 2 augments tissue repair and regeneration. Br. J. Pharmacol. 2025, 182 (22), 5536–5555. (共同第一作者,中科院2区)
(7) Qu, Q.; Chen, Y.; Wang, Y.; Wang, W.; Long, S.; Yang, H.-Y.; Wu, J.; Li, M.; Tian, X.; Wei, X.; Liu, Y.-H.; Xu, S.; Xiong, J.; Yang, C.; Wu, Z.; Huang, X.; Xie, C.; Wu, Y.; Xu, Z.; Zhang, C.; Zhang, B.; Feng, J.-W.; Chen, J.; Feng, Y.; Fang, H.; Lin, L.; Xie, Z. K.; Sun, B.; Tian, H.; Yu, Y.; Piao, H.-L.; Xie, X.-S.; Deng, X.; Zhang, C.-S.; Lin, S.-C. Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing. Nature 2025, 643 (8070), 201–209. (中科院1区)
(8) Hu, H.-H.; Wang, X.; Lan, B.; Cheng, H.; Wen, H.; Chen, F.; Wu, J.; Li, M.; Chen, J.; Zhang, J.; Chen, D.; Lin, S.; Lin, J.; Yang, M.; Wu, Z.; Zheng, Z.-Z.; Chen, F.; Zhou, J.; Chen, G.; Chen, Y.; Deng, X.; Zhang, C.-S.; Liu, J.; Lin, S.-C. Glucose starvation mimetic aldometanib removes immune barriers permitting mice with hepatocellular carcinoma to live to normal ages. Cell Res. 2025, 35 (12), 934–953. (中科院1区)
(9) Zhang, C.-S.; Li, M.; Wang, Y.; Li, X.; Zong, Y.; Long, S.; Zhang, M.; Feng, J.-W.; Wei, X.; Liu, Y.-H.; Zhang, B.; Wu, J.; Zhang, C.; Lian, W.; Ma, T.; Tian, X.; Qu, Q.; Yu, Y.; Xiong, J.; Liu, D.-T.; Wu, Z.; Zhu, M.; Xie, C.; Wu, Y.; Xu, Z.; Yang, C.; Chen, J.; Huang, G.; He, Q.; Huang, X.; Zhang, L.; Sun, X.; Liu, Q.; Ghafoor, A.; Gui, F.; Zheng, K.; Wang, W.; Wang, Z.-C.; Yu, Y.; Zhao, Q.; Lin, S.-Y.; Wang, Z.-X.; Piao, H.-L.; Deng, X.; Lin, S.-C. The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK. Nat. Metab. 2022, 4 (10), 1369–1401. (中科院1区)
(1) 邓贤明,黄伟,吴振华,吴亚闯,云彩红,张建明,黄鑫。专利名称:EGFR抑制剂、其制备方法与应用。授权年份:2023年,专利号:ZL 2021 1 0524157.4
(2) 邓贤明,黄伟,吴振华,吴亚闯,云彩红,张建明,黄鑫。专利名称:烯基嘧啶类化合物、其制备方法与应用。授权年份:2025年,专利号:ZL 2021 8 0041038.1
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